Description

August 20, 2010, 8:54 am • Tags: , ,

Theranostics is a term used to describe the proposed process of diagnostic therapy for individual patients. This involves testing for possible reaction to a new medication and tailoring a treatment based on the test results.

It encompasses the utilization of a wide range of subjects including predictive medicine, personalized medicine, integrated medicine and pharmacodiagnostics. The method is looked upon as the possible end result of new advances made in new drug discovery, molecular biology and microarray chips technology.

Although the use of the term Theranostics has been criticized as less than accurate, it is in line with today’s personalized approach to medicine, especially as it relates to cancer treatment. The stakes have never been higher to know that a drug therapy is working in real time than with cancer. Tumor responsiveness is critical to successful treatment and the term used to describe the process of making clinical treatment decisions mid-therapy in direct response to that precise therapy is Theranostics.

However, Theranostics is a confusing term and not understood by most professionals. There is no difficulty in describing this concept without using a special term, so if one needs to use a single word to describe a test linked to therapy, one can use pharmacodiagnostics, which is more appropriate and easy to understand.

Comeback

August 19, 2010, 9:18 am • Tags: , ,

A cancer survivor is an individual with cancer of any type, current or past, who is still living. About 11 million Americans alive today, or one in 30 people, are either currently undergoing treatment for cancer or have done so in the past. Nearly 65% of persons diagnosed with cancer are expected to live more than five years after the cancer is discovered.

Many cancer survivors describe the process of living with and beating cancer as a life-changing experience. It is not uncommon for this experience to bring about a personal epiphany, which the person uses as motivation to meet goals of great personal importance, such as climbing a mountain or reconciling with an estranged family member.

In October 1996, Lance Armstrong was diagnosed with testicular cancer, with a tumor that had metastasized to his brain and lungs. His cancer treatments included surgery and extensive chemotherapy, and his prognosis was originally poor. He went on to win the Tour de France each year from 1999 to 2005, and is the only person to win seven times.

In 1995, the Grammy-nominated American poet, activist and author Nikki Giovanni was diagnosed with lung cancer. Alive today, a 15-year survivor, she denies that her cancer has made her a better person, adding that “If it takes a near-death experience for you to appreciate your life, you’re wasting somebody’s time.”

Choices

August 14, 2010, 6:30 am • Tags: , ,

Genetic testing involves direct examination of the DNA molecule to detemine a person’s ancestry or vulnerabilities to inherited diseases. Genetic testing can provide only limited information about an inherited condition. The test can not determine if a person will show symptoms of a disorder, how severe the symptoms will be, or whether the disorder will progress over time.

The results of genetic tests are not always straightforward, which often makes them challenging to interpret and explain. Many of the risks associated with genetic testing involve the emotional, social, or financial consequences of the test results. The possibility of genetic discrimination in employment or insurance is also a concern. In the United States, the use of genetic information is governed by the Genetic Information Nondiscrimination Act.

Direct-to-Consumer genetic testing is a type of genetic test that is accessible directly to the consumer without having to go through a health care professional. Benefits of this type of testing are the accessibility of tests to consumers, promotion of proactive healthcare and the privacy of genetic information.

Some advertising for direct-to-consumer genetic testing has been criticized as conveying an exaggerated and inaccurate message about the connection between genetic information and disease risk, utilizing emotions as a selling factor. Consumers can potentially misinterpret genetic information, causing them to be deluded about their personal health.

Subtlety

May 13, 2010, 7:26 am • Tags: , ,

Suiseki is the Japanese art of stone appreciation and may also refer to the objects of the appreciation, the stones. Suiseki may take many forms including those that bear a resemblance to human figures, animal figures, landscape forms, and those which are purely abstract.

Natural stone and rock formations, with no artificial carvings, are preferred. Suiseki are sometimes carved and then thrown back into a lake so that any markings can be washed away with time. The stones can be any color, and contrasting colors are not uncommon.

The size of the stone can be quite varied. They can weigh hundreds of pounds or less than an ounce. Subtlety of color, shape, and markings is also desired, as is beauty of texture and shape. Suiseki are usually reminiscent of someone or something, or may convey a spiritual nature that moves viewers in some way.

One of the most important aspects of suiseki is the great care which is taken in displaying stones. They are usually set upon a stable surface, such as a rosewood pedestal that has been carved specifically for the stone. Suiseki should always be the predominant element and the container or surroundings should never detract from the stone.

Signals

April 29, 2010, 8:08 am • Tags: , ,

Numbers stations are shortwave radio stations of uncertain origin. They generally broadcast artificially generated voices reading streams of numbers, words, letters, tunes or Morse code. They are in a wide variety of languages and the voices are usually female, though sometimes male or children’s voices are used.

It has been reported that the United States uses numbers stations to communicate encoded information to persons in other countries. Others speculate that some of these stations may be related to illegal drug smuggling operations.

According to the notes of The Conet Project, numbers stations have been reported since World War I. They appear and disappear over time, although some follow regular schedules, and their overall activity has increased slightly since the early 1990s. This increase suggests that, as spy-related phenomena, they were not unique to the Cold War.

Numbers stations are often given nicknames by enthusiasts, often reflecting some distinctive element of the station such as their interval signal. For example, the “Lincolnshire Poacher” played the first two bars of the folk song “The Lincolnshire Poacher” before each string of numbers. “Magnetic Fields” plays music from French electronic musician Jean Michel Jarre before and after each set of numbers.

Mnemonic

April 22, 2010, 7:47 am • Tags: , ,

The Gregorian solar calendar counts days as the basic unit of time, grouping them into years of 365+ and repeats completely every 146,097 days, which fills 400 years, and which also happens to be 20,871 seven-day weeks. Each “year” lasts exactly 365.2425 days, or 365 days, 5 hours, 49 minutes and 12 seconds.

To compensate for this anomaly, the Gregorian year is divided into twelve arbitrary months of irregular length, with no regular relationship among their lengths. English speakers sometimes remember the number of days in each month of the Gregorian year by the use of the traditional mnemonic verse Thirty days hath September.

A language-independent alternative used in many countries is to hold up the fists with the index knuckle of the left hand against the index knuckle of the right hand. Then, starting with January from the little knuckle of the left hand, count knuckle, space, knuckle, space through the months. A knuckle represents a month of 31 days, and a space represents a short month. The junction between the hands is not counted, so the two index knuckles represent July and August.

A similar mnemonic can be found on a piano keyboard: starting on the key F for January, moving up the keyboard in semitones, the black notes give the short months, the white notes the long ones.

Particulate

April 10, 2010, 7:06 am • Tags: , ,

Galium aparine is an annual plant native to North America and Eurasia. It has several common names, including Bedstraw, Cleavers, Clivers, Goosegrass, Stickywilly, Stickyweed, Catchweed, Robin-run-the-hedge and Coachweed. The long stems of this climbing plant sprawl over the ground and other plants, reaching heights of 2-5 feet.

Both leaves and stem have fine hairs tipped with tiny hooks, making them cling to clothes and fur much like velcro. As they grow quite rampantly and thickly, they end up shading out any small plants that they overrun. The seeds are similar in size to cereal grains, and are a common contaminant in cereals since they are difficult to filter out. The presence of some seed in cereals is not considered a serious problem as they are not toxic.

When dried and roasted, the fruits of this plant can be used to make a coffee-like drink. The plant can also be made into a tea. Galium aparine was traditionally used to treat skin diseases. Herbalists use it to lower blood pressure and body temperature.

The whole plant is considered rich in vitamin C. Its roots produce a red dye, and the tea has been used as an anti-perspirant by the Chinese, and as a relief for head colds, restlessness, and sunburns. As a pulp, it has been used to relieve poisonous bites.

Bedstraw was widely used as a stuffing for mattresses during early medieval times from the 5th century through the 10th century. The densely paniculated flowers make for soft bedding.

Inertia

March 31, 2010, 8:19 am • Tags: , ,

The sailing stones are a geological phenomenon found in the Racetrack Playa located in the northern part of the Panamint Mountains in Death Valley National Park, California. The stones slowly move across the surface of the playa without human or animal intervention leaving a track as they go. They have never been seen or filmed in motion. Racetrack stones only move once every two or three years and most tracks last for just three or four years.

Stones with rough bottoms leave straight striated tracks while those with smooth bottoms wander. Stones sometimes turn over, exposing the other edge to the ground and leaving a different-sized track in the stone’s wake.

The sailing stones are most likely moved by strong winter winds of up to 90 mph. Once it has rained enough to fill the playa with just enough water to make the clay slippery, the winds push the stones across the slick surface. The prevailing winds across Racetrack Playa blow from southwest to northeast, with most of the rock trails parallel to this direction, lending support to this hypothesis.

An alternate hypothesis builds upon the first. As rain water accumulates, strong winds blow thin sheets of water quickly over the relatively flat surface of the playa. A layer of ice forms on the surface as night temperatures fall below freezing. Wind then drives these floating ice sheets, their aggregate inertia providing the necessary force required to move the larger stones.

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